Intestinal resident effector–memory CD4 T cells on the adaptive-innate spectrum comprise IL-18 reactivity and adaptive CMV specificity
Tobias Kammann, Isabel Voigt, Nicole Wild, Efthymia Kokkinou, Curtis Cai, Takuya Sekine, Vera Nilsén, Whitney Weigel, Chris Tibbitt, Christopher Stamper, Anne Marchalot, John Bassett, Jyotsana Kaushal, Sabrina Ferreira, Elli Mouchtaridi, Elisa J. M. Raineri, Thomas R. Müller, Olga Rivera Ballesteros · 2026
Read Intestinal resident effector–memory CD4 T cells on the adaptive-innate spectrum comprise IL-18 reactivity and adaptive CMV specificity by Tobias Kammann, Isabel Voigt, Nicole Wild, Efthymia Kokkinou, Curtis Cai, Takuya Sekine, Vera Nilsén, Whitney Weigel, Chris Tibbitt, Christopher Stamper, Anne Marchalot, John Bassett, Jyotsana Kaushal, Sabrina Ferreira, Elli Mouchtaridi, Elisa J. M. Raineri, Thomas R. Müller, Olga Rivera Ballesteros (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13178553.txt.
Description
Tobias Kammann and co-authors wrote a 2026 study on a special set of immune cells living in the human gut. Tissue-resident T cells guard barrier sites like the intestine, balancing defense against constant microbe contact. The team compared CD4 T cells across matched lymphoid and non-lymphoid tissues from the same donors.
One population stood out, enriched in the small intestine and liver. These cells carried markers of both adaptive immunity and innate-style readiness. They responded strongly to the alarm signal IL-18 and also held precise memory of cytomegalovirus, a common virus. Their profile mixed helper types and included tissue repair traits. The same cells were depleted in the colon of patients with inflammatory bowel disease. The findings widen the map of gut immunity.
Catalog record
| CREATOR | Tobias Kammann, Isabel Voigt, Nicole Wild, Efthymia Kokkinou, Curtis Cai, Takuya Sekine, Vera Nilsén, Whitney Weigel, Chris Tibbitt, Christopher Stamper, Anne Marchalot, John Bassett, Jyotsana Kaushal, Sabrina Ferreira, Elli Mouchtaridi, Elisa J. M. Raineri, Thomas R. Müller, Olga Rivera Ballesteros |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |