Helicase A determines the transcription program of TH17 lineage differentiation and autoimmunity
Yanhong Su, Anjun Jiao, Xiaoran Zhang, Yanan Xu, Huanxin Ping, Kun Zhu, Qiaohao Wang, Ning Yuan, Yang Gao, Bomiao Ju, Renyi Ding, Ni Wang, Lan He, Lei Lei, Yong Zhao, Mingzhen Zhang, Baojun Zhang · 2026
Read Helicase A determines the transcription program of TH17 lineage differentiation and autoimmunity by Yanhong Su, Anjun Jiao, Xiaoran Zhang, Yanan Xu, Huanxin Ping, Kun Zhu, Qiaohao Wang, Ning Yuan, Yang Gao, Bomiao Ju, Renyi Ding, Ni Wang, Lan He, Lei Lei, Yong Zhao, Mingzhen Zhang, Baojun Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13178542.txt.
Description
A family of immune cells called TH17 drives several autoimmune diseases, and a seventeen-author team has now mapped a master switch for the lineage. They noticed a nuclear helicase, Dhx9, rising alongside TH17 development in disease. Deleting its gene in mouse T cells cut TH17 formation sharply.
Animals without the helicase suffered far less in models of multiple sclerosis and rheumatoid arthritis. Inside the cell, the helicase opens the DNA at two core TH17 genes so the known driver factors can bind and switch them on. A partner protein, Nono, helps, and a natural compound, punicalagin, blocked the helicase and eased disease in mice. The authors present the helicase as the conductor of the TH17 program and as a drug target for calming autoimmunity.
Catalog record
| CREATOR | Yanhong Su, Anjun Jiao, Xiaoran Zhang, Yanan Xu, Huanxin Ping, Kun Zhu, Qiaohao Wang, Ning Yuan, Yang Gao, Bomiao Ju, Renyi Ding, Ni Wang, Lan He, Lei Lei, Yong Zhao, Mingzhen Zhang, Baojun Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |