Impact of Anti‐Inflammatory Drug Therapy on the Efficacy of First‐Line Atezolizumab Treatment in Patients With Advanced Non‐Small Cell Lung Cancer: An Integrated Analysis of Five Randomized Controlled Trials
Kazuki Takada, Alessio Cortellini, Shinkichi Takamori, Fumitaka Mizuki, David J Pinato, Mototsugu Shimokawa · 2026
Read Impact of Anti‐Inflammatory Drug Therapy on the Efficacy of First‐Line Atezolizumab Treatment in Patients With Advanced Non‐Small Cell Lung Cancer: An Integrated Analysis of Five Randomized Controlled Trials by Kazuki Takada, Alessio Cortellini, Shinkichi Takamori, Fumitaka Mizuki, David J Pinato, Mototsugu Shimokawa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13177338.txt.
Description
Kazuki Takada and co-authors report a 2026 analysis of whether common pain and fever drugs dull a leading lung cancer immunotherapy. Drugs like acetaminophen and other anti-inflammatory agents may blunt the immune attack on tumors. The team pooled patient-level data from five randomized trials of atezolizumab in advanced lung cancer.
Across 3,781 patients, about 15 percent had taken acetaminophen and about a third had taken the other class. Acetaminophen use tracked with worse survival and faster progression in both the immunotherapy and comparison groups. The other drug class showed no link in the immunotherapy group, though it tracked with worse outcomes without the drug. The pattern hints that acetaminophen's effect is not specific to immunotherapy. The study gives doctors a reason to review routine pain relief in this setting.
Catalog record
| CREATOR | Kazuki Takada, Alessio Cortellini, Shinkichi Takamori, Fumitaka Mizuki, David J Pinato, Mototsugu Shimokawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |