Extended Sustained Release of Propranolol Hydrochloride from Siloxane-Poly(propylene Oxide) Hybrid Material: A Multistep Mechanism
Ranielle de Oliveira Silva, Karim Dahmouche, Celso V. Santilli · 2026
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Description
Silva, Dahmouche, and Santilli design a hybrid material that releases a heart drug slowly for up to two months in this 2026 study. Their carrier mixes flexible polymer chains with glass-like siloxane nodes, made by a catalyst-free sol-gel route. The blend is amphiphilic, part water-loving and part water-shunning.
The drug, propranolol hydrochloride, survived the network formation intact, confirmed by silicon NMR. At low loading, five percent, release ran nearly continuously. At thirty percent, it turned stair-like, because more drug sat as crystals between the oily chains. Water entered the matrix so slowly that a wet skin formed over a dry core. Several non-standard release mechanisms then took turns, giving the extended profile.
Catalog record
| CREATOR | Ranielle de Oliveira Silva, Karim Dahmouche, Celso V. Santilli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |