Lineage‐Specific Adaptive Strategies Shape the Response of de Novo Lager Yeast Hybrids to High‐Gravity Fermentation
Sonia Albillos‐Arenal, Vasni Zavaleta, Fernanda Jeria, Darío González‐Venegas, Tomás A Peña, Pablo Villarreal, Francisco A Cubillos · 2026
Read Lineage‐Specific Adaptive Strategies Shape the Response of de Novo Lager Yeast Hybrids to High‐Gravity Fermentation by Sonia Albillos‐Arenal, Vasni Zavaleta, Fernanda Jeria, Darío González‐Venegas, Tomás A Peña, Pablo Villarreal, Francisco A Cubillos (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13176630.txt.
Description
Albillos-Arenal and six co-authors present a study from twenty twenty-six on how new lager yeast hybrids adapt to strong brewing. Lager yeast arose from a cross of two parent species long ago. The team breed fresh hybrids from distinct parent lineages. They evolve those hybrids for two hundred fifty generations under high-gravity brewing stress. Weaker starters gain the most fitness, a pattern of shrinking returns. Over half the evolved lines outproduce their ancestors in gas output. The ale parent's background shapes adaptation far more than the cold parent does.
Two evolved lines show opposite genomic strategies. One rewires large chromosome chunks with few gene changes. The other stacks many gene-breaking changes across pathways. The authors frame the setup as a replay of yeast domestication.
Catalog record
| CREATOR | Sonia Albillos‐Arenal, Vasni Zavaleta, Fernanda Jeria, Darío González‐Venegas, Tomás A Peña, Pablo Villarreal, Francisco A Cubillos |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |