ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB
Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox · 2026
Read ID93 + GLA-3M-052-LS vaccine candidate administered by heterologous routes improves BCG efficacy against TB by Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13176160.txt.
Description
Emily Voigt and co-authors test a tuberculosis vaccine booster given by mixed routes, in a 2026 study. The old BCG vaccine protects children but fades in adults. Tuberculosis still kills more than a million people yearly. The candidate vaccine pairs a fused TB antigen with a modern adjuvant blend.
The team varied the adjuvant mix and the route of delivery. Some doses went into muscle and others to mucosal surfaces. Mice from a TB-susceptible strain received the shots, then faced infection. Immune responses were measured in blood and in the airways. Certain route mixes improved on BCG protection. The results guide which candidate moves toward human trials. Mucosal immunity looks key for a lung disease.
Catalog record
| CREATOR | Emily Voigt, Anas Alsharaydeh, Darshan N. Kasal, Madeleine Farber Jennewein, Devin S. Brandt, Susan Lin, Jasneet Singh, Julie Bakken, Raodoh Mohamath, Pauline Fusco, Jordi B. Torrelles, Gillian Beamer, Christopher B. Fox |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |