Hyperbaric oxygen therapy alters bowel perfusion and improves outcomes in patients with treatment-refractory ulcerative colitis: a prospective pilot trial
Lieven Mulders, Maarten Pruijt, Joep Van Oostrom, Esmerij Van Der Zanden, Andra Neefjes-Borst, Pim Koelink, Manon Wildenberg, Wouter De Jonge, Milan Ridderikhof, Rob Van Hulst, Geert D’Haens, Krisztina Gecse · 2026
Read Hyperbaric oxygen therapy alters bowel perfusion and improves outcomes in patients with treatment-refractory ulcerative colitis: a prospective pilot trial by Lieven Mulders, Maarten Pruijt, Joep Van Oostrom, Esmerij Van Der Zanden, Andra Neefjes-Borst, Pim Koelink, Manon Wildenberg, Wouter De Jonge, Milan Ridderikhof, Rob Van Hulst, Geert D’Haens, Krisztina Gecse (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13175981.txt.
Description
Mulders and co-authors test pressurized oxygen therapy for ulcerative colitis that has resisted modern drugs, in a 2026 pilot trial. Sixteen patients who had already failed at least two advanced therapies received ten or twenty daily sessions breathing pure oxygen at 2.4 atmospheres, alongside their usual medication. Response was judged at twelve weeks by combined symptom and camera criteria.
Two of eight patients responded in the shorter course and four of eight in the longer one, with improvements across clinical, endoscopic, and ultrasound measures. Responders' bowel blood flow rose while non-responders' fell. The therapy was well tolerated, with no serious side effects, and the authors call for a randomized dose-finding trial.
Catalog record
| CREATOR | Lieven Mulders, Maarten Pruijt, Joep Van Oostrom, Esmerij Van Der Zanden, Andra Neefjes-Borst, Pim Koelink, Manon Wildenberg, Wouter De Jonge, Milan Ridderikhof, Rob Van Hulst, Geert D’Haens, Krisztina Gecse |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |