Transposable elements shape stemness in normal and leukemic hematopoiesis
Giacomo Grillo, Bettina Nadorp, Aditi Qamra, Bryce Drylie, Amanda Mitchell, Christopher Arlidge, Ankita Nand, Naoya Takayama, Alex Murison, Seyed Ali Madani Tonekaboni, Komaldeep Kaur Kang, Andrea Arruda, Jean C Y Wang, Mark D Minden, Özgen Deniz, Héléna Boutzen, John E Dick, Mathieu Lupien · 2026
Read Transposable elements shape stemness in normal and leukemic hematopoiesis by Giacomo Grillo, Bettina Nadorp, Aditi Qamra, Bryce Drylie, Amanda Mitchell, Christopher Arlidge, Ankita Nand, Naoya Takayama, Alex Murison, Seyed Ali Madani Tonekaboni, Komaldeep Kaur Kang, Andrea Arruda, Jean C Y Wang, Mark D Minden, Özgen Deniz, Héléna Boutzen, John E Dick, Mathieu Lupien (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13175892.txt.
Description
A large team shows that jumping genes, called transposable elements, help set whether blood stem cells stay primitive or mature. The question matters in acute myeloid leukemia, where stem-like cells drive relapse after treatment, yet two-thirds of patients who first remit later relapse. The team read chromatin openness across leukemia stem cells, normal blood stem cells, and their descendants. Patterns at 121 families of these elements separated stem-like cells from mature ones.
Those same patterns sorted patients by stemness and by survival. The elements act as docking sites for proteins that fold the genome or switch on cell-type programs, including one tied to leukemia stem cells. Editing one family shut in the lab broke the cells' stemness. The authors conclude that distinct element families underpin stemness in healthy and leukemic blood alike.
Catalog record
| CREATOR | Giacomo Grillo, Bettina Nadorp, Aditi Qamra, Bryce Drylie, Amanda Mitchell, Christopher Arlidge, Ankita Nand, Naoya Takayama, Alex Murison, Seyed Ali Madani Tonekaboni, Komaldeep Kaur Kang, Andrea Arruda, Jean C Y Wang, Mark D Minden, Özgen Deniz, Héléna Boutzen, John E Dick, Mathieu Lupien |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |