Effects and adaptation of high-altitude hypoxia on lipid metabolism: mechanisms and health implications
Yu Fan, WeiWei Guo, LiXin Yang, HaiQi Xu · 2026
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Description
Yu Fan, WeiWei Guo, LiXin Yang, and HaiQi Xu review how thin air at high altitude reshapes fat metabolism in this 2026 paper. At altitude, the body gets less oxygen with each breath. That shortage forces deep changes in how fats are stored, moved, and burned.
The review gathers evidence from two groups: peoples born to high land, such as Tibetans and Andeans, and lowlanders who travel up. A sudden climb triggers fast fat release, more sugar burning, and swings in blood lipid levels. With time, the body adapts toward fuels that use oxygen more efficiently. Adapted groups often burn less fat, handle insulin better, and show distinct lipid profiles. The picture differs for those who never adapt, where harm can follow. The authors weigh the health stakes of each pattern.
Catalog record
| CREATOR | Yu Fan, WeiWei Guo, LiXin Yang, HaiQi Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |