Proteomic insights into aprotinin’s immunomodulatory effects in attenuating renal fibrosis in a unilateral ureteral obstruction model
Xinyu Wang, Ying Shen, Danlei Chen, Lele Ding, Yuanlong Ding, Peilin Gan, Qian Long, Lu Song, Yaling Li, Xin Tian, Jun Zhang, Jian Xu, Yutaka Kakizoe, Shu Yang, Fucheng Luo, Qinyuan Deng · 2026
Read Proteomic insights into aprotinin’s immunomodulatory effects in attenuating renal fibrosis in a unilateral ureteral obstruction model by Xinyu Wang, Ying Shen, Danlei Chen, Lele Ding, Yuanlong Ding, Peilin Gan, Qian Long, Lu Song, Yaling Li, Xin Tian, Jun Zhang, Jian Xu, Yutaka Kakizoe, Shu Yang, Fucheng Luo, Qinyuan Deng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13175798.txt.
Description
Xinyu Wang and co-authors test a drug's effect on kidney scarring in a 2026 mouse paper. Aprotinin is a drug that blocks a broad set of protein-cutting enzymes. Its effects on the kidney depend on dose, and its role in blockage-related kidney damage was unclear.
In mice with one blocked urinary tract, a higher daily dose reduced tube injury and tissue scarring over seven days, while a lower dose barely helped. Protein scans showed the drug calmed immune pathways and cut a protein involved in presenting antigens to immune cells. Treated kidneys held fewer helper T cells of one type and more of a naive type. The higher dose slightly raised blood waste markers, a trade-off the authors flag for follow-up.
Catalog record
| CREATOR | Xinyu Wang, Ying Shen, Danlei Chen, Lele Ding, Yuanlong Ding, Peilin Gan, Qian Long, Lu Song, Yaling Li, Xin Tian, Jun Zhang, Jian Xu, Yutaka Kakizoe, Shu Yang, Fucheng Luo, Qinyuan Deng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |