A single-cell multi-omics assay for simultaneous measurement of vector copy number and protein expression in CAR T cells
Yilong Yang, Saurabh Parikh, Chieh-Yuan Li, Lindsey Murphy, Khushali Patel, Qawer Ayaz, Mahir Mohiuddin, John T Elliott, Hua-Jun He, Zhiyong He, Samantha Maragh, Benjamin Schroeder, Terry J Fry, Amanda Winters, Shu Wang · 2026
Read A single-cell multi-omics assay for simultaneous measurement of vector copy number and protein expression in CAR T cells by Yilong Yang, Saurabh Parikh, Chieh-Yuan Li, Lindsey Murphy, Khushali Patel, Qawer Ayaz, Mahir Mohiuddin, John T Elliott, Hua-Jun He, Zhiyong He, Samantha Maragh, Benjamin Schroeder, Terry J Fry, Amanda Winters, Shu Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13175768.txt.
Description
Chimeric antigen receptor T cell (CAR T) immunotherapies have transformed cancer treatment. These therapies typically involve lentiviral vector-mediated CAR gene integration, followed by reinfusion into patients, necessitating rigorous quality control. Critical parameters, including transduction efficiency and vector copy number (VCN), must be accurately quantified.
Catalog record
| CREATOR | Yilong Yang, Saurabh Parikh, Chieh-Yuan Li, Lindsey Murphy, Khushali Patel, Qawer Ayaz, Mahir Mohiuddin, John T Elliott, Hua-Jun He, Zhiyong He, Samantha Maragh, Benjamin Schroeder, Terry J Fry, Amanda Winters, Shu Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |