Leukocyte Telomere Length and Its Polygenic Risk Score in Post‐Stroke Cognitive Impairment: Evidence From a Multicenter Cohort Study
Kunying Zhao, Yanfeng Shi, Hongyi Yan, Hongyu Zhou, Jiejie Li, Si Cheng, Zhe Xu, Yuesong Pan, Zixiao Li, Xia Meng, Hao Li, Xiaoling Liao, Jing Jing, Yongjun Wang · 2026
Read Leukocyte Telomere Length and Its Polygenic Risk Score in Post‐Stroke Cognitive Impairment: Evidence From a Multicenter Cohort Study by Kunying Zhao, Yanfeng Shi, Hongyi Yan, Hongyu Zhou, Jiejie Li, Si Cheng, Zhe Xu, Yuesong Pan, Zixiao Li, Xia Meng, Hao Li, Xiaoling Liao, Jing Jing, Yongjun Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13175197.txt.
Description
Kunying Zhao and thirteen co-authors tested whether chromosome-cap length predicts thinking problems after stroke in a 2026 cohort study. Telomeres in white blood cells mark biological aging and have been tied to cognition. The team drew on a large Chinese stroke registry, measuring telomere length from genome data and building a genetic risk score from eighteen variants.
Among 923 patients checked a year after stroke, about one in five had cognitive impairment. Neither telomere length nor the genetic score predicted impairment overall. Exploratory splits hinted that effects might differ by age and stroke subtype, but the authors treat those as leads only. The result tempers hopes that this aging marker can flag at-risk stroke survivors.
Catalog record
| CREATOR | Kunying Zhao, Yanfeng Shi, Hongyi Yan, Hongyu Zhou, Jiejie Li, Si Cheng, Zhe Xu, Yuesong Pan, Zixiao Li, Xia Meng, Hao Li, Xiaoling Liao, Jing Jing, Yongjun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |