334 Delineating the immune landscape of Kaposi Sarcoma using multiplexed immunofluorescence at single-cell resolution
Dicle Yalcin, Guobin Kang, Zoe Davidson, Danielle M Shea, Salum J Lidenge, Owen Ngalamika, Charles Wood, John T West · 2026
Read 334 Delineating the immune landscape of Kaposi Sarcoma using multiplexed immunofluorescence at single-cell resolution by Dicle Yalcin, Guobin Kang, Zoe Davidson, Danielle M Shea, Salum J Lidenge, Owen Ngalamika, Charles Wood, John T West (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13173211.txt.
Description
Dicle Yalcin and co-authors map immune cells in Kaposi sarcoma, a tumor tied to a virus called KSHV. Their 2026 study is the first use of a new imaging platform for this task. The tool can mark many cell types in one run, at single cell level. Panels were tuned to sort cells in tumor tissue and compare them with nearby normal areas.
The highest virus load sat in cells with markers of vessel lining origin. Twelve other cell types each held the virus in under one percent of cells. Killer T cells sat close to or on top of infected cells, hinting they attack them. Areas rich in T cells were also found near normal vessel cells. That pattern hints at immune traffic toward the tumor.
Catalog record
| CREATOR | Dicle Yalcin, Guobin Kang, Zoe Davidson, Danielle M Shea, Salum J Lidenge, Owen Ngalamika, Charles Wood, John T West |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |