419 Sepsis-associated PARDS is associated with an exhausted neutrophil phenotype in the lower respiratory tract
James Williams, Nirmeen Elmadany, Brian Varisco · 2026
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Description
James Williams, Nirmeen Elmadany, and Brian Varisco study severe lung failure in sick children. Their 2026 paper deals with cases tied to sepsis, a life threatening response to infection. Children in the study are under eighteen, in intensive care, and on a breathing tube. Samples are taken from the airway and from blood on days one, three, and seven.
The team reads genes cell by cell to map the immune cells present. Early work on five samples from two children found 31,330 cells. Most were immune cells. Two kinds of neutrophils stood out. One kind looked worn out in the lower airway. The authors say this pattern may mark a distinct type of the illness and guide care.
Catalog record
| CREATOR | James Williams, Nirmeen Elmadany, Brian Varisco |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |