374 Targeting disrupted neural circuits to treat PTSD with comorbid psychosis
Olivia Yang, Hannah B. Elam, Stephanie M. Perez, Daniel J. Lodge · 2026
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Description
Olivia Yang and co-authors target broken brain circuits in rats to treat trauma stress with psychosis. Their 2026 study records activity of dopamine neurons in a midbrain area after stress. A drug that blocks orexin receptors, called suvorexant, is tested. The circuit at issue runs from the insular cortex to a frontal area. Both chemical and drug methods were used to alter that path.
Foot shock stress raised dopamine neuron activity sharply. Giving the drug into the frontal area reversed the effect. Blocking the circuit by chemical means did the same. That confirms the path's role, the authors say. Light based measures showed the drug cut signals in the frontal area. The work names a circuit that may mediate stress driven dopamine harm.
Catalog record
| CREATOR | Olivia Yang, Hannah B. Elam, Stephanie M. Perez, Daniel J. Lodge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |