37 Injured proximal tubule cells are increased in kidney transplant rejection and are spatially located in distinct niches containing mixed immune cells
John Caldwell, Yunguan Wang, Tiffany Shi, Ashley Burg, Ashley Koby, Krishna E Steve, Woodle Roskin, David A Hildeman · 2026
Read 37 Injured proximal tubule cells are increased in kidney transplant rejection and are spatially located in distinct niches containing mixed immune cells by John Caldwell, Yunguan Wang, Tiffany Shi, Ashley Burg, Ashley Koby, Krishna E Steve, Woodle Roskin, David A Hildeman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13173062.txt.
Description
John Caldwell and co-authors map injured kidney cells during transplant rejection in a 2026 study. Rejection is a top cause of graft loss, and standard biopsy reads focus on immune cells, saying little about recovery chances. The team sequenced single cells from twenty-five biopsies of fifteen patients with acute cellular rejection.
They sorted kidney cells into healthy, injured, and damaged states, homing in on the most common type, proximal tubule cells. Injured forms of these cells grew more common with worse rejection. Spatial mapping on tissue sections then located the injured cells in distinct niches crowded with mixed immune cells. The work begins to explain how kidney and immune cells interact during rejection.
Catalog record
| CREATOR | John Caldwell, Yunguan Wang, Tiffany Shi, Ashley Burg, Ashley Koby, Krishna E Steve, Woodle Roskin, David A Hildeman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |