405 Uncovering population-specific signals and hundreds of new loci from a multi-ancestry study of blood pressure traits in over 2.5M individuals
Hannah Seagle, Jeewoo Kim, Joseph H Breeyear, Catherine A Greene, John B Buse, Lanna Caruth, Lindsay Guare, Navya S Josyula, Qianqian Liang, Chelsea Okeh, Hannah Poisner, Yash Pershad, Serena Houghton, Yuk-Lam Anne Ho, Xiaofeng Zhu, Alexander G Bick, Digna R Velez Edwards, J Michael Gaziano, Alison · 2026
Read 405 Uncovering population-specific signals and hundreds of new loci from a multi-ancestry study of blood pressure traits in over 2.5M individuals by Hannah Seagle, Jeewoo Kim, Joseph H Breeyear, Catherine A Greene, John B Buse, Lanna Caruth, Lindsay Guare, Navya S Josyula, Qianqian Liang, Chelsea Okeh, Hannah Poisner, Yash Pershad, Serena Houghton, Yuk-Lam Anne Ho, Xiaofeng Zhu, Alexander G Bick, Digna R Velez Edwards, J Michael Gaziano, Alison (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13172992.txt.
Description
Hannah Seagle and co-authors run a genome wide study of blood pressure traits in more than 2.5 million people. Their 2026 study spans sixteen cohorts and biobanks. Forty percent of people were of non-European ancestry. Traits were the top and lower pressure numbers, plus the gap between them. Scans were run across all ancestries and within each ancestry group.
Models adjusted for age, sex, body mass, and genetic background. Fine mapping sought loci specific to one population. In all, 2,406 loci were tied to the top pressure number. Of those, 1,594 were novel. For the lower number, 2,358 loci were found. The team also checked chromosome X and tested for signs of evolutionary pressure on pressure risk.
Catalog record
| CREATOR | Hannah Seagle, Jeewoo Kim, Joseph H Breeyear, Catherine A Greene, John B Buse, Lanna Caruth, Lindsay Guare, Navya S Josyula, Qianqian Liang, Chelsea Okeh, Hannah Poisner, Yash Pershad, Serena Houghton, Yuk-Lam Anne Ho, Xiaofeng Zhu, Alexander G Bick, Digna R Velez Edwards, J Michael Gaziano, Alison |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |