Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude
Hongqiao Chen, Mingli Chen, Lian Meng, Xing Wei, Yan Qin, Zhumei Bi · 2026
Read Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude by Hongqiao Chen, Mingli Chen, Lian Meng, Xing Wei, Yan Qin, Zhumei Bi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13172942.txt.
Description
Hongqiao Chen and co-authors nominate a vitamin as a stroke protector by following a gene the data kept pointing at. Their 2026 study mines gene expression datasets with machine learning and finds ID3, a transcription regulator, consistently switched down in acute ischemic stroke, with levels tracking how severe the neurological damage is.
Network pharmacology predicted pantothenic acid, vitamin B5, as a compound that targets ID3. In a cell model of stroke, oxygen and glucose starvation followed by reperfusion, the vitamin raised ID3, calmed inflammation signals, and restored the neurons' firing amplitude. The chain is integrative rather than definitive: computation nominated, cells confirmed a first effect. Neuroprotection after stroke is a graveyard of failed drugs, so the authors claim a candidate, not a cure. Their contribution is a testable target pair, gene and vitamin, with a mechanism story connecting them.
Catalog record
| CREATOR | Hongqiao Chen, Mingli Chen, Lian Meng, Xing Wei, Yan Qin, Zhumei Bi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |