235 From barriers to breakthroughs: Addressing accrual barriers in pragmatic EHR-embedded trials
Bethany Kwan, Bethany M Kwan, Cecilia Low Wang, Lindsay A Lennox, Sarah V Kautz, Adit A Ginde, Matthew Mimnall, Andrew Nicklawsky, Goldie Komaie, Christine Velez, Aaron Barbour, Neil Aggarwal, Marjorie McIntyre, Ronald J Sokol, Thomas W Flaig · 2026
Read 235 From barriers to breakthroughs: Addressing accrual barriers in pragmatic EHR-embedded trials by Bethany Kwan, Bethany M Kwan, Cecilia Low Wang, Lindsay A Lennox, Sarah V Kautz, Adit A Ginde, Matthew Mimnall, Andrew Nicklawsky, Goldie Komaie, Christine Velez, Aaron Barbour, Neil Aggarwal, Marjorie McIntyre, Ronald J Sokol, Thomas W Flaig (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13172826.txt.
Description
Bethany Kwan and co-authors tackle barriers to sign up in trials built into health records. Their 2026 study centers on a pragmatic trial for prostate cancer. It compares a diabetes drug with lifestyle change. Sign up via records is limited by workflow and communication issues, the authors note. A root cause analysis was used to find barriers and guide fixes.
The trial required two consents, one for a research consortium and one for the trial itself. The team rebuilt the full sign up path in a diagram. Talks were held with ten eligible patients and four clinicians. Two kinds of fix emerged. Patient focused fixes track consent status and message patients before visits. Clinician focused fixes send tailored record based messages before eligible visits and give targeted teaching to staff.
Catalog record
| CREATOR | Bethany Kwan, Bethany M Kwan, Cecilia Low Wang, Lindsay A Lennox, Sarah V Kautz, Adit A Ginde, Matthew Mimnall, Andrew Nicklawsky, Goldie Komaie, Christine Velez, Aaron Barbour, Neil Aggarwal, Marjorie McIntyre, Ronald J Sokol, Thomas W Flaig |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |