Decoding the S1P-S1PR axis in cancer: Mechanisms, pathways and therapeutic horizons (Review)
Yun-Ta Chuang, I-Hui Wu, Cheng-Fan Lee, Hsinyu Lee · 2026
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Description
Chuang and co-authors present a 2026 review on a lipid signal system that tumors hijack. The signal, called S1P, works through five receptors on cell surfaces. In healthy tissue the system guards blood vessels and steers immune cells. In cancer it feeds growth, new vessels, immune escape, and spread.
Tumors rewire the system at many levels, from gene switches to receptor placement, the authors show. Extra fuel for making S1P teams up with those receptor changes to lock in the cancer state. The review sorts each receptor's role one by one. It ends with drug strategies aimed at the axis and the resistance it breeds.
Catalog record
| CREATOR | Yun-Ta Chuang, I-Hui Wu, Cheng-Fan Lee, Hsinyu Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |