Bu-Fei Formula Ameliorates Inflammation in a Preclinical COPD-Like Model by Targeting Mitochondrial Hyperactivity to Inhibit the NLRP3 Inflammasome
Tong Yang, Yang Liu, Xingli Sun, Genyan Liu, Jiayin Ning, Lang Liu, Jiangqin Ou · 2026
Read Bu-Fei Formula Ameliorates Inflammation in a Preclinical COPD-Like Model by Targeting Mitochondrial Hyperactivity to Inhibit the NLRP3 Inflammasome by Tong Yang, Yang Liu, Xingli Sun, Genyan Liu, Jiayin Ning, Lang Liu, Jiangqin Ou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13172628.txt.
Description
Tong Yang and co-authors test a traditional Chinese herbal formula in a 2026 lab study of lung disease. COPD leaves airways inflamed and airflow limited for good. The formula, Bu-Fei, eases symptoms in clinic use, but the molecular route of its help was a knowledge gap. The team traces that route to the cell's power plants and a known inflammation switch.
They built a COPD-like model in rats with cigarette smoke and a bacterial trigger, and a cell model with smoke extract. The formula was given for eight weeks at rising doses. Stains and electron images checked lung harm, scarring, and the shape of immune cells. Measures of the switch, called the NLRP3 inflammasome, and its products showed the formula calms hyperactive mitochondria, which in turn holds the switch down.
Catalog record
| CREATOR | Tong Yang, Yang Liu, Xingli Sun, Genyan Liu, Jiayin Ning, Lang Liu, Jiangqin Ou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |