Zone-specific hepatocytes orchestrate the early onset of host immune defenses during Staphylococcus aureus bloodstream infection
Obiageli V. Nwofor, Alexander Leipold, Qian Chen, Robert Geffers, Antoine-Emmanuel Saliba, Oliver Goldmann, Eva Medina · 2026
Read Zone-specific hepatocytes orchestrate the early onset of host immune defenses during Staphylococcus aureus bloodstream infection by Obiageli V. Nwofor, Alexander Leipold, Qian Chen, Robert Geffers, Antoine-Emmanuel Saliba, Oliver Goldmann, Eva Medina (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13171408.txt.
Description
Obiageli Nwofor and co-authors study how zones of the liver shape the early immune defense against Staphylococcus aureus in the blood, in a 2026 study. Bloodstream infections are life-threatening, and this bacterium is among the most lethal causes. The liver is the main site where blood-borne germs are first caught and cleared. Its response is known to vary by zone, with spatial and cell-level specialization.
No direct evidence had linked liver zones to the response to bloodstream infection. The team use an infection model where the germ is injected into a vein. The liver caught about ninety percent of the circulating bacteria within four hours and cut the blood load a great deal. Their work maps how zone-specific liver cells lead the early defense.
Catalog record
| CREATOR | Obiageli V. Nwofor, Alexander Leipold, Qian Chen, Robert Geffers, Antoine-Emmanuel Saliba, Oliver Goldmann, Eva Medina |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |