Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hematological patients with severe iatrogenic immunosuppression
Emmanouil Karofylakis, Theodoros Loupis, Andromachi Blizou, Eleni Ntalaouti, Eirini Maria Stergioti, Giannis Vatsellas, Sotirios Tsiodras, Anastasia Antoniadou, Aggelos Banos, Konstantinos Thomas · 2026
Read Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hematological patients with severe iatrogenic immunosuppression by Emmanouil Karofylakis, Theodoros Loupis, Andromachi Blizou, Eleni Ntalaouti, Eirini Maria Stergioti, Giannis Vatsellas, Sotirios Tsiodras, Anastasia Antoniadou, Aggelos Banos, Konstantinos Thomas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13171318.txt.
Description
Emmanouil Karofylakis and nine colleagues track how the COVID virus evolves inside patients whose immune systems are weakened by treatment, in a paper dated twenty twenty-six. Such patients can carry the virus for long stretches, letting it change. The team followed twenty-six patients with rheumatic or blood diseases on strong immune-suppressing care. Virus gene reads came from airway samples over time.
Most patients were hospitalized and some died. Rare mutations appeared in the virus's copying genes and in its spike. In patients with paired samples, small variants piled up at a steady rate. The build-up rate did not differ between the two disease groups. The authors warn these hidden changes could seed escape variants.
Catalog record
| CREATOR | Emmanouil Karofylakis, Theodoros Loupis, Andromachi Blizou, Eleni Ntalaouti, Eirini Maria Stergioti, Giannis Vatsellas, Sotirios Tsiodras, Anastasia Antoniadou, Aggelos Banos, Konstantinos Thomas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |