BNIP3‐Dependent Mitophagy Non‐Autonomously Regulates Systemic Aging via NF‐κB Suppression in Drosophila
Zhouyang Deng, Hailong Han, Caifang Wang, Wen Zhong, Zhengqing Wan, Dan Zhou, Ye Chen, Yanni Peng, Zongzhao Zhai, Kai Yuan, Ruoxi Wang, Zhuohua Zhang · 2026
Read BNIP3‐Dependent Mitophagy Non‐Autonomously Regulates Systemic Aging via NF‐κB Suppression in Drosophila by Zhouyang Deng, Hailong Han, Caifang Wang, Wen Zhong, Zhengqing Wan, Dan Zhou, Ye Chen, Yanni Peng, Zongzhao Zhai, Kai Yuan, Ruoxi Wang, Zhuohua Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13171292.txt.
Description
Zhouyang Deng and eleven co-authors published a 2026 fruit fly study of how cleaning up damaged mitochondria in muscle slows aging body-wide. The team built a reporter to watch mitophagy, the disposal of worn mitochondria, in living flies. Muscle mitophagy fell with age, while damaged proteins, reactive oxygen, and broken mitochondria piled up. Boosting one driver, BNIP3, in muscle kept mitochondria intact and cleared the reactive oxygen.
The striking part: muscle-only BNIP3 lengthened life and eased brain aging signs, from protein clumps to tissue damage. The mechanism ran through blocking an immune pathway that reactive oxygen switches on. The authors present direct evidence of muscle-to-brain signaling. The work links organ-level housekeeping to whole-body aging.
Catalog record
| CREATOR | Zhouyang Deng, Hailong Han, Caifang Wang, Wen Zhong, Zhengqing Wan, Dan Zhou, Ye Chen, Yanni Peng, Zongzhao Zhai, Kai Yuan, Ruoxi Wang, Zhuohua Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |