Emulating a target trial of early compared with late initiation of appropriate antibiotic therapy for hospital-acquired monobacterial Gram-negative bloodstream infections
Abdullah T Aslan, Yukiko Ezure, Elif Seren Tanriverdi, Osman Dağ, Cansu Cimen, Ayşe Kaya Kalem, Bircan Kayaaslan, Sevil Alkan, Bahadır Köylü, Emine Büşra Ata, Bilge Çağlar, Neşe Saltoğlu, Uğur Önal, Seçil Deniz, Onur Ural, Murtaza Öz, Mehmet Bakir, Mesut Yilmaz, Rümeysa Çakmak, Ayşe Batirel, Özlem A · 2026
Read Emulating a target trial of early compared with late initiation of appropriate antibiotic therapy for hospital-acquired monobacterial Gram-negative bloodstream infections by Abdullah T Aslan, Yukiko Ezure, Elif Seren Tanriverdi, Osman Dağ, Cansu Cimen, Ayşe Kaya Kalem, Bircan Kayaaslan, Sevil Alkan, Bahadır Köylü, Emine Büşra Ata, Bilge Çağlar, Neşe Saltoğlu, Uğur Önal, Seçil Deniz, Onur Ural, Murtaza Öz, Mehmet Bakir, Mesut Yilmaz, Rümeysa Çakmak, Ayşe Batirel, Özlem A (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13171036.txt.
Description
Abdullah Aslan and a large team of co-authors studied antibiotic timing in serious bloodstream infections in a 2026 paper. These infections, caught in hospital and caused by one kind of resistant-prone bacteria, kill more patients when the right drug starts late. A true randomized trial of delay would be unethical, so the team imitated one.
They used records from twenty-two Turkish hospitals on adults with this infection. Statistical weighting made the early and late treatment groups comparable, as a trial's coin flip would. The main measure was death within fourteen days, with twenty-eight days as a backup. The design, called a target trial emulation, is meant to give trial-grade answers from routine care data. The study adds structured evidence on how fast the right antibiotic must start in hospital-acquired infections.
Catalog record
| CREATOR | Abdullah T Aslan, Yukiko Ezure, Elif Seren Tanriverdi, Osman Dağ, Cansu Cimen, Ayşe Kaya Kalem, Bircan Kayaaslan, Sevil Alkan, Bahadır Köylü, Emine Büşra Ata, Bilge Çağlar, Neşe Saltoğlu, Uğur Önal, Seçil Deniz, Onur Ural, Murtaza Öz, Mehmet Bakir, Mesut Yilmaz, Rümeysa Çakmak, Ayşe Batirel, Özlem A |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |