Simultaneous Presentation of Hemophagocytic Lymphohistiocytosis and Classical Hodgkin’s Lymphoma in a Patient with Underlying Germline Homozygous STXBP2 Mutation
Shilpa Gupta, Amrita Rajendran, Akanksha Chichra, Ayubali Qureshi · 2026
Read Simultaneous Presentation of Hemophagocytic Lymphohistiocytosis and Classical Hodgkin’s Lymphoma in a Patient with Underlying Germline Homozygous STXBP2 Mutation by Shilpa Gupta, Amrita Rajendran, Akanksha Chichra, Ayubali Qureshi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13170815.txt.
Description
Shilpa Gupta and co-authors report a patient who developed both an immune overdrive syndrome and Hodgkin lymphoma on a background of an inherited gene defect, in a 2026 case report. The syndrome, HLH, makes the immune system attack the body. It usually strikes children with faulty killer-cell genes. One such gene is STXBP2, which the patient carried in two copies.
Adult cases of primary HLH are rare and often missed. Lymphoma and immune defects are known to travel together. A weak immune system may fail to stop cancers early. The case joins those threads in a single patient. Doctors gain a reminder to test genes in adult HLH. Families may need screening once such a defect is found.
Catalog record
| CREATOR | Shilpa Gupta, Amrita Rajendran, Akanksha Chichra, Ayubali Qureshi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |