MAK‐2 Kinase Is Required for Extended Longevity and Enhanced Stress Resistance Resulting From Mild Impairment of Mitochondrial Function in isp‐1 Mutants
Ulrich Anglas, Abdelrahman Alokda, Shusen Zhu, Aura A. Tamez González, Ekin Celtikcioglu, Jiaxi Guan, Maisha M. Promi, Grant F. Booth, Alain Pacis, Jeremy M. Van Raamsdonk · 2026
Read MAK‐2 Kinase Is Required for Extended Longevity and Enhanced Stress Resistance Resulting From Mild Impairment of Mitochondrial Function in isp‐1 Mutants by Ulrich Anglas, Abdelrahman Alokda, Shusen Zhu, Aura A. Tamez González, Ekin Celtikcioglu, Jiaxi Guan, Maisha M. Promi, Grant F. Booth, Alain Pacis, Jeremy M. Van Raamsdonk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13169497.txt.
Description
Ulrich Anglas and nine co-authors study long life in worms in 2026. A mild flaw in the worms' cell power plants, from a mutation called isp-1, stretches lifespan and stress resistance. Signals from the power plants to the nucleus seem to switch on resilience genes, but the wiring was unclear.
Removing a kinase called MAK-2 erased the lifespan and stress gains in the mutant worms, yet left normal worms untouched. A parallel kinase path proved needed as well. Gene reads showed many mutant-driven gene shifts depend on MAK-2, above all in immunity and stress genes. The kinase thus relays the power plant's signal.
Catalog record
| CREATOR | Ulrich Anglas, Abdelrahman Alokda, Shusen Zhu, Aura A. Tamez González, Ekin Celtikcioglu, Jiaxi Guan, Maisha M. Promi, Grant F. Booth, Alain Pacis, Jeremy M. Van Raamsdonk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |