MUC1-targeting small peptide radiopharmaceuticals for breast cancer
Rim Malek, Madeleine Landry, Pierre Cheung, Corinne Beinat · 2026
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Description
Rim Malek, Madeleine Landry, Pierre Cheung, and Corinne Beinat test small peptides meant to carry radioactive tags to breast tumors, in this 2026 paper. The target is MUC1, a protein that appears in excess, with stripped sugars, on many breast cancers. Past peptides all aimed at one exposed stretch of the protein. The team tried all three minimal stretches.
They built compounds around each stretch and varied the linker that joins peptide to tag, from water-loving to fat-loving. One reference compound entered cells most, but the uptake of all compounds was low. Worse, none showed true specificity: cells lacking MUC1 took them up just as well. Binding tests found no firm grip at all, and mouse tests agreed. The authors report the negative result plainly and say their group has moved to screening vast peptide libraries for a real binder.
Catalog record
| CREATOR | Rim Malek, Madeleine Landry, Pierre Cheung, Corinne Beinat |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |