Managing fatigue with methylphenidate and physical activity during cancer immunotherapy treatment
Sriram Yennurajalingam, Bryan Fellman, Lisa Williams, Karen Basen-Engquiest, Eduardo Bruera · 2026
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Description
Sriram Yennurajalingam and co-authors pilot a paired attack on cancer fatigue during immunotherapy: a stimulant plus daily activity. Fatigue in advanced cancer is common and crushing, with few proven helps. Their study enrolls patients on anti-PD1 therapy with strong fatigue scores. Forty patients were randomized for fourteen days. All got a set activity plan. Half also got self-dosed methylphenidate, and half a placebo.
Thirty-four patients could be fully judged. Fatigue scores improved a lot in both arms. Mood and global fatigue gauges moved the same way. The design cannot credit the drug alone, since activity itself may lift fatigue. The team frames the pilot as groundwork for a larger, sharper trial.
Catalog record
| CREATOR | Sriram Yennurajalingam, Bryan Fellman, Lisa Williams, Karen Basen-Engquiest, Eduardo Bruera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |