Tumor-Derived Exosomal PDLIM1 Promotes Angiogenesis and Tumor Progression in Papillary Thyroid Carcinoma: Insights From Integrated Single-Cell Transcriptomics and Exosomal Proteomics
Wangwang Qiu, Ting Yan, Xinyu Huang, Youben Fan, Jianzhong Di, Zhili Yang · 2026
Read Tumor-Derived Exosomal PDLIM1 Promotes Angiogenesis and Tumor Progression in Papillary Thyroid Carcinoma: Insights From Integrated Single-Cell Transcriptomics and Exosomal Proteomics by Wangwang Qiu, Ting Yan, Xinyu Huang, Youben Fan, Jianzhong Di, Zhili Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13165480.txt.
Description
Wangwang Qiu and co-authors trace how thyroid cancer cells spread by shipping a protein to blood vessel cells, in a 2026 paper. Papillary thyroid cancer can metastasize, and the cellular chatter behind that spread is poorly mapped. Tumor cells release tiny parcels called exosomes that carry proteins to other cells.
The team profiled single cells from primary and spread tumors in four patients and flagged cell states tied to spread. A growth signal pathway ran hot in those states. Matching parcel protein data pointed to one protein, PDLIM1, rich in cancer cells and spread tissue. Vessel cells took it in and grew more vessel branches in dishes. Blocking the protein in models slowed that effect. The authors name it a driver of spread.
Catalog record
| CREATOR | Wangwang Qiu, Ting Yan, Xinyu Huang, Youben Fan, Jianzhong Di, Zhili Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |