Roflumilast Enhances Liraglutide’s Atrial Natriuretic Peptide-Dependent Suppression of Adrenal Aldosterone Secretion
Ariana Hosseini, Alexis J. M’Sadoques, Renee A. Stoicovy, Victoria L. Altsman, Laura Raynshteyn, Emma Weinstein, Teresa Baggio Lopez, Giselle Del Calvo, Madyson G. Leiker, Anastasios Lymperopoulos · 2026
Read Roflumilast Enhances Liraglutide’s Atrial Natriuretic Peptide-Dependent Suppression of Adrenal Aldosterone Secretion by Ariana Hosseini, Alexis J. M’Sadoques, Renee A. Stoicovy, Victoria L. Altsman, Laura Raynshteyn, Emma Weinstein, Teresa Baggio Lopez, Giselle Del Calvo, Madyson G. Leiker, Anastasios Lymperopoulos (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13164327.txt.
Description
Ariana Hosseini and colleagues report a 2026 lab study on two drugs that may work better together. Liraglutide, a drug used for blood sugar and weight, also helps the heart release a hormone called ANP. That hormone tells the adrenal gland to make less aldosterone, a salt-and-pressure hormone. The team asked whether roflumilast, which blocks an enzyme that breaks down a key cell signal, could boost this chain.
In heart muscle cells grown in the lab, liraglutide did raise ANP release, and roflumilast made the effect stronger. Blocking steps in the chain cut the effect back down. Fluid from treated heart cells also curbed aldosterone output from adrenal cells. The results suggest a fresh way the two drugs might jointly ease strain on the heart and blood pressure.
Catalog record
| CREATOR | Ariana Hosseini, Alexis J. M’Sadoques, Renee A. Stoicovy, Victoria L. Altsman, Laura Raynshteyn, Emma Weinstein, Teresa Baggio Lopez, Giselle Del Calvo, Madyson G. Leiker, Anastasios Lymperopoulos |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |