Hematopoietic Aging and Leukemia: Mechanistic and Therapeutic Insights
Zhihui Li, Hao Zhang, Nuo Cheng, Hong Li, Xiaoling Wang, Jingbo Shao · 2026
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Description
Zhihui Li and five co-authors review how aging of the blood-forming system raises the risk of leukemia, in a 2026 paper. As people age, the stem cells that make blood lose renewal power, favor some cell lines over others, and reshape the marrow around them. These shifts make blood cancers more likely, while leukemia itself speeds aging through the body. The exact chain of causes is still being worked out.
Recent work points to changed clone patterns, long-running inflammation, and altered energy use in the marrow niche. The review pulls these threads together to show how an aging blood system can tip toward cancer. It also discusses treatment ideas that might slow or reverse those changes, a growing hope as populations age.
Catalog record
| CREATOR | Zhihui Li, Hao Zhang, Nuo Cheng, Hong Li, Xiaoling Wang, Jingbo Shao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |