Neurodegenerative Diseases in Children: A Comprehensive Review
Constantin Ailioaie, Laura Marinela Ailioaie, Cristinel Ionel Stan, Anca Sava, Dragos Andrei Chiran · 2026
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Description
Constantin Ailioaie and co-authors review degenerative brain diseases in children in a 2026 paper. These disorders are rare one by one but add up to a real burden. Unlike adult forms, most childhood cases are genetic, rooted in broken cell machinery such as waste disposal, energy production, fat handling, or the insulation of nerve fibers.
The review covers how often these diseases occur, how they are classed, and how they unfold. Damage builds through stored toxins, stalled cleanup, failing energy supply, and inflammation. Gene sequencing, metabolic profiling, and better scans have sharpened diagnosis, even before birth in some screening programs. Care is shifting from support alone toward targeted tools: enzyme replacement, stem cell transplants, and gene therapy. Early molecular diagnosis, the authors stress, decides how much those tools can help.
Catalog record
| CREATOR | Constantin Ailioaie, Laura Marinela Ailioaie, Cristinel Ionel Stan, Anca Sava, Dragos Andrei Chiran |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 105 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |