Repositioning of Fluoroquinolones: A New Approach in Antitumor Therapy
Jeferson Ricardo da Silva, Jaqueline Barbosa de Souza, Lara Limeira de Oliveira, Luís André de Almeida Campos, Isabella Macário Ferro Cavalcanti · 2026
Read Repositioning of Fluoroquinolones: A New Approach in Antitumor Therapy by Jeferson Ricardo da Silva, Jaqueline Barbosa de Souza, Lara Limeira de Oliveira, Luís André de Almeida Campos, Isabella Macário Ferro Cavalcanti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13162834.txt.
Description
Jeferson Ricardo da Silva and four co-authors review the case for reusing fluoroquinolone antibiotics as cancer drugs. These familiar antibacterials also slow cancer cell growth in the laboratory, which makes them tempting candidates for repositioning. The review gathers studies from 2013 to 2023 on their antitumor effects.
The drugs appear to jam the cell cycle, push cancer cells toward programmed death, and raise oxidative stress inside them. They also touch drivers of tumor spread, including a gene that helps cells change identity and migrate. Mixing them with standard cancer drugs can strengthen the effect. Packing them into slow-release carriers is another active idea. The authors conclude the field is promising but young: the mechanisms need fuller mapping before clinical protocols can be written.
Catalog record
| CREATOR | Jeferson Ricardo da Silva, Jaqueline Barbosa de Souza, Lara Limeira de Oliveira, Luís André de Almeida Campos, Isabella Macário Ferro Cavalcanti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |