Understanding Sickle Cell Disease Endothelial Pathology Through the Lens of Liver Sinusoidal Endothelial Cells
Tirthadipa Pradhan-Sundd, Brian Branchford, Joan Beckman · 2026
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Description
Tirthadipa Pradhan-Sundd, Brian Branchford, and Joan Beckman review blood vessel damage in sickle cell disease in a 2026 article, with a focus on the liver. Activation of endothelial cells, which line vessels, is a core feature of the disease. It drives acute crises and chronic organ damage across many tissues.
The review gathers clinical and lab evidence on markers of vessel activation and damage in different tissue beds. It then centers on liver sinusoidal endothelial cells, which clear hemoglobin, shape inflammation, and mediate liver injury. Possible therapies aimed at reversing damage from their dysfunction are discussed.
Catalog record
| CREATOR | Tirthadipa Pradhan-Sundd, Brian Branchford, Joan Beckman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |