Cognitive effects of intravenous Ketamine in treatment-resistant depression: A systematic review
Lou-Anne Chavigny, Véronique Desbeaumes Jodoin, Nicolas Garel, Manola Sob Ndongo, Laura Osborne, Gustavo Turecki, Stéphane Richard Devantoy · 2026
Read Cognitive effects of intravenous Ketamine in treatment-resistant depression: A systematic review by Lou-Anne Chavigny, Véronique Desbeaumes Jodoin, Nicolas Garel, Manola Sob Ndongo, Laura Osborne, Gustavo Turecki, Stéphane Richard Devantoy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13161796.txt.
Description
Lou-Anne Chavigny and colleagues review what ketamine, given in a vein, does to the thinking of people with hard-to-treat depression, in this review from twenty twenty-six. Twenty-one studies, with about a thousand people, tested skills from speed of thought to memory. The worry: a drug that can cloud the mind might harm it.
The pattern was the reverse. Speed of thought and working memory often improved. Attention held, or improved a bit. The mental braking tested by Stroop tasks got better in several trials. Results for verbal and visual memory were mixed. No study found that thinking got worse. Two studies tied those gains to less suicidal thinking. The authors suggest that better executive control may be one route of ketamine's antisuicidal action. They ask for standard long-term studies to test how long the gains last.
Catalog record
| CREATOR | Lou-Anne Chavigny, Véronique Desbeaumes Jodoin, Nicolas Garel, Manola Sob Ndongo, Laura Osborne, Gustavo Turecki, Stéphane Richard Devantoy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |