Astrocyte Heterogeneity in Multiple Sclerosis From Reactive Glia to Therapeutic Targets
Byung-Jo Kim · 2026
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Description
Byung-Jo Kim introduces a review that recasts star-shaped brain cells as lead actors in multiple sclerosis. The disease was long read through immune cells alone, with astrocytes cast as bystanders. New tools that read single cells and map tissue have changed that picture. Astrocytes now appear as active regulators that can worsen or repair damage.
Kim weighs what the shift means for treatment. Animal models defined many astrocyte subtypes, but how far they match human disease stays unsure. Late-onset and progressive forms raise the stakes, since aging and inflammation feed each other there. Patients with late onset reach disability steps faster than same-age peers. The editorial argues that closing the gap between model and human is the field's next task. Astrocyte types could then become drug targets.
Catalog record
| CREATOR | Byung-Jo Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |