Multiple vertebrae improves precision in image-based bone marrow absorbed dose estimation in [177Lu]Lu–DOTATATE treatment
Katja Smits, Frida Westerbergh, Jens Hemmingsson, Martijn van Essen, Johanna Svensson, Anna-Lena Theisen, Johannes Tran-Gia, Tobias Rydén, Peter Bernhardt · 2026
Read Multiple vertebrae improves precision in image-based bone marrow absorbed dose estimation in [177Lu]Lu–DOTATATE treatment by Katja Smits, Frida Westerbergh, Jens Hemmingsson, Martijn van Essen, Johanna Svensson, Anna-Lena Theisen, Johannes Tran-Gia, Tobias Rydén, Peter Bernhardt (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13161456.txt.
Description
Katja Smits and co-authors refine radiation dose estimates for a cancer therapy in a 2026 study. The treatment sends a radioactive drug to neuroendocrine tumors, and the bone marrow is the organ most at risk. Image-based marrow dose guesses are noisy because few spine bones are sampled.
Sixteen patients were studied, alongside lab and digital phantoms. Counting six vertebrae instead of one cut the spread of dose estimates from 34 percent to about 6 percent. Scanner rebuilding settings barely moved the result. Small phantom volumes were noisier than large ones, as expected. The authors recommend multi-vertebra sampling for steadier dose checks in clinic.
Catalog record
| CREATOR | Katja Smits, Frida Westerbergh, Jens Hemmingsson, Martijn van Essen, Johanna Svensson, Anna-Lena Theisen, Johannes Tran-Gia, Tobias Rydén, Peter Bernhardt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |