Modifiable risk factors attenuated longevity genetic predisposition on life expectancy in the oldest old
Shimin Chen, Ke Han, Shengshu Wang, Shanshan Yang, Yueting Shi, Wenchang Wang, Shengyan Du, Xiaoxin Ye, Yanhao Wan, Jianhua Wang, Miao Liu, Yao He · 2026
Read Modifiable risk factors attenuated longevity genetic predisposition on life expectancy in the oldest old by Shimin Chen, Ke Han, Shengshu Wang, Shanshan Yang, Yueting Shi, Wenchang Wang, Shengyan Du, Xiaoxin Ye, Yanhao Wan, Jianhua Wang, Miao Liu, Yao He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13161428.txt.
Description
Shimin Chen and co-authors ask whether healthy habits can outweigh genes for long life in the very old. Their 2026 study follows 1,545 people aged 80 and up in a Chinese centenarian cohort. A score summed 11 changeable risk factors, and a gene score summed variants tied to long life.
A favourable habit profile cut death risk by about 40 percent against the worst profile. A favourable gene score cut it by about 13 percent. People lucky on both counts had the lowest risk of all, gaining near seven extra years at age 80. A poor habit profile largely erased the gene edge. The authors stress habit care even in advanced age.
Catalog record
| CREATOR | Shimin Chen, Ke Han, Shengshu Wang, Shanshan Yang, Yueting Shi, Wenchang Wang, Shengyan Du, Xiaoxin Ye, Yanhao Wan, Jianhua Wang, Miao Liu, Yao He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |