Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data
Philip S Nash, Gareth Ambler, Jonathan G Best, Duncan Wilson, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y H Lip, Simon Fandler-Höfler, Sebastian Eppinger, Kaori Miwa, Masayuki Shiozawa, Masatoshi Koga, Martina B Goeldlin, Morin Beyeler, Philipp Bücke, Marwan El-Koussy, Heinrich P M · 2026
Read Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data by Philip S Nash, Gareth Ambler, Jonathan G Best, Duncan Wilson, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y H Lip, Simon Fandler-Höfler, Sebastian Eppinger, Kaori Miwa, Masayuki Shiozawa, Masatoshi Koga, Martina B Goeldlin, Morin Beyeler, Philipp Bücke, Marwan El-Koussy, Heinrich P M (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13160420.txt.
Description
Philip Nash and a large international team ask whether overworking kidneys spell danger after a stroke, in this 2026 study. The trait in question is glomerular hyperfiltration, when the kidneys filter blood faster than is normal for a person's age and sex. It had been tied to death in other groups but barely studied in stroke patients.
The team pooled records for 11,175 stroke and mini-stroke patients from many cohort studies. About five percent met the hyperfiltration mark at presentation. Those patients died at more than twice the rate of the normal-filtration group. After adjustment, their risk of death from any cause was about seventy-six percent higher, and vascular death was also clearly raised. Risk rose at both very low and very high filtration rates, giving a U-shaped pattern. The authors suggest the high end of kidney function deserves the same worry as the low end after stroke.
Catalog record
| CREATOR | Philip S Nash, Gareth Ambler, Jonathan G Best, Duncan Wilson, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y H Lip, Simon Fandler-Höfler, Sebastian Eppinger, Kaori Miwa, Masayuki Shiozawa, Masatoshi Koga, Martina B Goeldlin, Morin Beyeler, Philipp Bücke, Marwan El-Koussy, Heinrich P M |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |