Design and synthesis of an erdafitinib-based selective FGFR2 degrader
Yumeng Jin, Shidong Wang, Sihan Pan, Shuqi Huang, Weichen Zhou, Xiaohao Huang, Lei Zheng, Lingfeng Chen, David Spring · 2026
Read Design and synthesis of an erdafitinib-based selective FGFR2 degrader by Yumeng Jin, Shidong Wang, Sihan Pan, Shuqi Huang, Weichen Zhou, Xiaohao Huang, Lei Zheng, Lingfeng Chen, David Spring (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13159326.txt.
Description
A peer-reviewed research article from Europe PMC (2026). This study aimed to develop a novel degrader capable of selectively degrading fibroblast growth factor receptor 2 (FGFR2) to overcome the issues of drug resistance and adverse reactions associated with traditional inhibitors in the treatment of FGFR2-driven tumors. Erdafitinib was employed as the targeting ligand, and its aliphatic amine site was conjugated with a CRBN E3 ligase ligand to design and synthesize a series of PROTAC molecules with different linkers.
Catalog record
| CREATOR | Yumeng Jin, Shidong Wang, Sihan Pan, Shuqi Huang, Weichen Zhou, Xiaohao Huang, Lei Zheng, Lingfeng Chen, David Spring |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |