Propranolol monotherapy versus combined propranolol-gabapentin for prevention of paroxysmal sympathetic hyperactivity after moderate-severe traumatic brain injury: a randomized controlled trial
Essamedin M Negm, Ahmed M Gouda, Mohammed El Mowafy Khatab, Essam Mohamed Elsayed Youssef, AnaSimon Alfred Foad Eskandr, Ola Mohammed Fathi, Heba Mohammed Fathi · 2026
Read Propranolol monotherapy versus combined propranolol-gabapentin for prevention of paroxysmal sympathetic hyperactivity after moderate-severe traumatic brain injury: a randomized controlled trial by Essamedin M Negm, Ahmed M Gouda, Mohammed El Mowafy Khatab, Essam Mohamed Elsayed Youssef, AnaSimon Alfred Foad Eskandr, Ola Mohammed Fathi, Heba Mohammed Fathi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13159313.txt.
Description
Essamedin Negm and six colleagues test two drug shields against storm attacks after severe brain injury. The complication, paroxysmal sympathetic hyperactivity, fires episodes of racing pulse, fever, sweating, and stiffening. It stretches ventilator time and hospital stays, and no guideline yet backs a preventive drug.
Ninety adults with moderate to severe injuries split three ways: standard care, standard care plus propranolol, or that drug plus gabapentin. Storm rates fell from sixty percent on standard care to ten percent on the pair. Propranolol alone gave the shortest ventilator and intensive care stays. Death rates did not differ. The authors back early preventive dosing while calling for larger trials.
Catalog record
| CREATOR | Essamedin M Negm, Ahmed M Gouda, Mohammed El Mowafy Khatab, Essam Mohamed Elsayed Youssef, AnaSimon Alfred Foad Eskandr, Ola Mohammed Fathi, Heba Mohammed Fathi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |