Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits
Rajinikanth Gogiraju, Beichen Sun, Magdalena L Bochenek, Ilka Wittig, Flávia Rezende, Melina Lopez, Angela Wirth, Wenjia Zhao, Elsa W Böhm, Payal Guliani, Kateryna Moiko, Michael Molitor, Philip Wenzel, Marc Freichel, Philipp Lurz, Ralf P Brandes, Katrin Schäfer · 2026
Read Loss of erythrocyte arginase-1 impairs vasorelaxation due to endothelial GSNOR overexpression and denitrosylation of G protein subunits by Rajinikanth Gogiraju, Beichen Sun, Magdalena L Bochenek, Ilka Wittig, Flávia Rezende, Melina Lopez, Angela Wirth, Wenjia Zhao, Elsa W Böhm, Payal Guliani, Kateryna Moiko, Michael Molitor, Philip Wenzel, Marc Freichel, Philipp Lurz, Ralf P Brandes, Katrin Schäfer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13158624.txt.
Description
Rajinikanth Gogiraju and a large team of co-authors report a 2026 mouse study with a paradox: deleting an enzyme from red blood cells loosened blood pressure yet blunted vessel relaxation. The enzyme's excess in red cells was already tied to stiff vessels, and blocking it briefly helped. The long game of its loss was unknown.
Knockout mice ran lower pressure and higher blood nitrite, with signs of an overactive relaxing signal in vessel muscle. Yet their lining cells overmade a cleanup enzyme that strips a key tag from signaling proteins, uncoupling the relax signal from its effect. Inducible deletion in the lining alone told a cleaner story. The authors map a red cell to lining conversation that guards vessel tone.
Catalog record
| CREATOR | Rajinikanth Gogiraju, Beichen Sun, Magdalena L Bochenek, Ilka Wittig, Flávia Rezende, Melina Lopez, Angela Wirth, Wenjia Zhao, Elsa W Böhm, Payal Guliani, Kateryna Moiko, Michael Molitor, Philip Wenzel, Marc Freichel, Philipp Lurz, Ralf P Brandes, Katrin Schäfer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |