A vitronectin-functionalized ECM-mimetic hydrogel platform for modelling integrin-dependent tumour responses to cilengitide
Isaac Vieco-Martí, Sofia Granados-Aparici, Amparo López-Carrasco, Miguel F. Segura, Manuel Salmerón-Sánchez, Inmaculada Noguera, Samuel Navarro, Rosa Noguera · 2026
Read A vitronectin-functionalized ECM-mimetic hydrogel platform for modelling integrin-dependent tumour responses to cilengitide by Isaac Vieco-Martí, Sofia Granados-Aparici, Amparo López-Carrasco, Miguel F. Segura, Manuel Salmerón-Sánchez, Inmaculada Noguera, Samuel Navarro, Rosa Noguera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13158391.txt.
Description
Isaac Vieco-Martí and co-authors build a gel that mimics body tissue so tumor response to a grip-blocking drug can be studied in the lab, in work from 2026. Real tissue scaffolds steer how tumor cells stick, sense force, and answer drugs. Few lab models copy that signaling while still fitting standard tissue workflows.
Their gel blends gelatin and silk proteins, dressed with a chosen adhesion protein. Cells grow inside in a tissue-like layout. A drug that blocks the cells' grip hooks can be added on cue. The gel survives slicing and staining for pathology review, and living cells and DNA can be pulled back out. Marker proteins for adhesion are read by imaging.
Catalog record
| CREATOR | Isaac Vieco-Martí, Sofia Granados-Aparici, Amparo López-Carrasco, Miguel F. Segura, Manuel Salmerón-Sánchez, Inmaculada Noguera, Samuel Navarro, Rosa Noguera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |