ADAM12 Stabilizes EIF3B to Promote Glycolysis and Tumor Progression in Hepatocellular Carcinoma
Shengdong Wu, Yongfei Zhu, Yan Xia, Shengjun Wu, Caide Lu · 2026
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Description
Shengdong Wu, Yongfei Zhu, Yan Xia, Shengjun Wu, and Caide Lu wrote a 2026 paper on a protein that helps liver cancer grow. This cancer is fast-moving and has few good treatments. The protein, ADAM12, shows up in excess in many cancers, and the team asked what it does in liver tumors.
They found the protein in high amounts in tumor tissue, and patients with more of it lived shorter lives. Cutting it back in lab cells slowed growth, movement, and spread, and tumors in mice grew less. The protein works by shielding a second protein that boosts the tumor's sugar burning. That chain gives drug hunters two possible targets in one pathway.
Catalog record
| CREATOR | Shengdong Wu, Yongfei Zhu, Yan Xia, Shengjun Wu, Caide Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |