Hyperbaric Oxygen Reverses High-Glucose–Induced Stemness and Radioresistance in Non-Small Cell Lung Cancer Cells
Jui-Ying Lee, Chia-Li Chung, Tzu-Ting Tseng, Shih-Hsun Kuo, Yu-Peng Liu, Ming-Tsang Wu, Hung-Pei Tsai, Aij-Lie Kwan · 2026
Read Hyperbaric Oxygen Reverses High-Glucose–Induced Stemness and Radioresistance in Non-Small Cell Lung Cancer Cells by Jui-Ying Lee, Chia-Li Chung, Tzu-Ting Tseng, Shih-Hsun Kuo, Yu-Peng Liu, Ming-Tsang Wu, Hung-Pei Tsai, Aij-Lie Kwan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13157848.txt.
Description
Jui-Ying Lee and co-authors find that sugar can armor lung cancer against radiation, and that pressurized oxygen strips the armor off. Chronic high glucose pushed two lung cancer cell lines toward stem-like behavior. They formed more tumorspheres, survived irradiation better, and raised the stemness factors SOX2 and OCT4, driven through the hypoxia signal HIF-1α.
Daily hyperbaric oxygen for four weeks, though not one, reversed the pattern. Stemness factors fell, sphere formation was suppressed, and the radiation resistance melted, while the glucose transporter level barely moved. The authors frame hyperbaric oxygen as a candidate adjunct for diabetic or hyperglycemic patients whose tumors radiotherapy struggles to kill, at least at the preclinical stage.
Catalog record
| CREATOR | Jui-Ying Lee, Chia-Li Chung, Tzu-Ting Tseng, Shih-Hsun Kuo, Yu-Peng Liu, Ming-Tsang Wu, Hung-Pei Tsai, Aij-Lie Kwan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |