Phase 1 multicenter study of the NKG2A targeting antibody S095029 as a single agent and in combination with anti-PD-1 in patients with advanced malignancies
Aung Naing, Anna Spreafico, Minal Barve, Amita Patnaik, Xenophon Ianopoulos, Pauline Drean, Niels Jorgen Skartved, Agnes Hemon, Chahrazade Kantari-Mimoun, Peng He, Vasileios Askoxylakis, Nehal Lakhani · 2026
Read Phase 1 multicenter study of the NKG2A targeting antibody S095029 as a single agent and in combination with anti-PD-1 in patients with advanced malignancies by Aung Naing, Anna Spreafico, Minal Barve, Amita Patnaik, Xenophon Ianopoulos, Pauline Drean, Niels Jorgen Skartved, Agnes Hemon, Chahrazade Kantari-Mimoun, Peng He, Vasileios Askoxylakis, Nehal Lakhani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13157761.txt.
Description
Aung Naing, Anna Spreafico, Minal Barve, and a team of co-authors report the first human trial of an antibody designed to release a brake on immune cells. The drug blocks a receptor that quiets natural killer and T cells when it meets its partner on tumor cells. Lab work hinted it pairs well with a second drug that blocks the PD-1 brake.
Patients with advanced solid tumors that had already resisted other treatments received the new antibody alone or with its partner. The drugs were well tolerated at every dose tried, with no dose-limiting harm. A few patients in each group saw their tumors shrink partly, and about a fifth gained lasting benefit. Blood tests confirmed the drug reached and engaged its target as designed.
Catalog record
| CREATOR | Aung Naing, Anna Spreafico, Minal Barve, Amita Patnaik, Xenophon Ianopoulos, Pauline Drean, Niels Jorgen Skartved, Agnes Hemon, Chahrazade Kantari-Mimoun, Peng He, Vasileios Askoxylakis, Nehal Lakhani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |