Metabolic Reprogramming and Immune Metabolism in Sepsis: Targeting the PPAR Pathway for Personalized Therapeutic Approaches
Zheqian Wu, Yisheng Chen, Lili Yin, Liming Zhu, Fei Ding, Lihua Dai, Stéphane MANDARD · 2026
Read Metabolic Reprogramming and Immune Metabolism in Sepsis: Targeting the PPAR Pathway for Personalized Therapeutic Approaches by Zheqian Wu, Yisheng Chen, Lili Yin, Liming Zhu, Fei Ding, Lihua Dai, Stéphane MANDARD (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13157310.txt.
Description
Zheqian Wu and co-authors review how the body's fuel handling goes wrong in sepsis, and how one drug-target family might correct it. Their 2026 review concerns the runaway infection response that shuts organs down. Immune cells under septic stress flip to a fast sugar-burning mode, which yields quick energy but floods tissues with lactate and wrecks their power plants.
The PPAR pathway, a set of switches that govern fat and sugar use, is the proposed lever for rebalancing. Since sepsis differs from patient to patient, the authors argue for personalized metabolic therapy rather than one recipe. The review gathers the case for trials aimed at these switches.
Catalog record
| CREATOR | Zheqian Wu, Yisheng Chen, Lili Yin, Liming Zhu, Fei Ding, Lihua Dai, Stéphane MANDARD |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |