A double-blind randomised controlled trial protocol comparing dexamphetamine and placebo effectiveness for obesity management in primary care settings
Natalie Gauci, Emily Hibbert, Hazer Khalifa, Alison Poulton · 2026
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Description
Natalie Gauci, Emily Hibbert, Hazer Khalifa, and Alison Poulton present a trial protocol from two thousand twenty-six testing dexamphetamine for obesity in primary care. Obesity carries a heavy health and economic load, and cheap, scalable treatments are scarce. The stimulant drug is inexpensive and curbs appetite, but its long-term value for weight control needs a rigorous test.
The double-blind trial assigns patients by chance to the drug or a placebo, alongside diet and lifestyle support, for six months of treatment and two years of follow-up. Doses start low and rise weekly as tolerated, with weekly checks during titration and monthly ones later. A rating scale guides dose changes, with a taper in the final month. The authors argue success could offer general practice a practical tool.
Catalog record
| CREATOR | Natalie Gauci, Emily Hibbert, Hazer Khalifa, Alison Poulton |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |