CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression
Yun-Han Lai, Duen-Yi Huang, Yen-Yu Chang, Yen-Lin Huang, Wan-Wan Lin · 2026
Read CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression by Yun-Han Lai, Duen-Yi Huang, Yen-Yu Chang, Yen-Lin Huang, Wan-Wan Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13156893.txt.
Description
Yun-Han Lai and co-authors study a scaffold protein that drives lung cancer growth in a 2026 paper. The protein, CASK, was high in early-stage tumors of the most common lung cancer type, and high levels went with shorter survival. Its role in the disease was poorly known, so the team silenced it in cancer cells and watched what changed.
Without CASK, cells stopped growing, held at a gate in their cycle by a brake protein called p21. Blocking that brake restored growth, proving its central place. The team traced a web of signals in which CASK holds p21 down through a growth receptor and its pathways. They say CASK is a new driver of this cancer and a possible drug target.
Catalog record
| CREATOR | Yun-Han Lai, Duen-Yi Huang, Yen-Yu Chang, Yen-Lin Huang, Wan-Wan Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |